Abstract: Under the background of the integrated development of the Yangtze River Delta into a national strategy, it is of great significance to study the impact of coordinated innovation on economic growth in the Yangtze River Delta Urban Agglomeration(YRDUA). Based on the data(2007-2017) of 26 cities in the YRDUA, the dynamic change characteristics of coordinated innovation development of urban agglomerations is studied by constructing the collaborative innovation spatial contact gravity model and the collaborative innovation spatial correlation model. Then, the impact of coordinated innovation on economic growth is explored by spatial lag model. The result shows that in the YRDUA, there are obvious regional differences in the spatial connection strength of collaborative innovation, but the overall spatial connection of collaborative innovation is increasing; the spatial linkage of collaborative innovation presents significant spatial correlation, and spatial agglomeration is obvious; basically, the innovation cluster district with Shanghai, Suzhou, Nanjing and Hangzhou as the endpoints of high collaborative innovation capability has been formed; the collaborative innovation has a significant spatial spillover effect, which promoted the regional economic growth through direct effect, indirect effect and total effect. Therefore, to improve the integrated development of the YRDUA, we should strengthen the spatial linkages of collaborative innovation with the YRDUA, make central cities play a more active role and further the collaborative innovation system in the YRDUA.