Uncertainty, as a structural force and embodied experience of modern social development, has profoundly affected the development of social work theory and practice, prompting the paradigm of social work knowledge production to transform from professional certainty to fuzzy generation. This uncertainty is reflected in several aspects such as knowledge foundation, research paradigm, production subject, production field, knowledge structure and knowledge characteristics. In this regard, it is necessary to recognize uncertainty as theoretical foundation, construct a social work knowledge system of uncertainty with the knowledge perspective of holistic representation, the research paradigm of complex narrative, the value purpose of subject empowerment, the action configuration of situational practice, the network configuration of integrative orientation, and the theoretical connotation of reflective perspective, and consequently realize the deep innovation and diversified development of the knowledge paradigm of social work.