Promoting the integration and high-quality development of culture and tourism of the city cluster in the Yangtze River Delta is an important way to implement the national strategy of the regional integration of the Yangtze River Delta and build a world-class city cluster in the Yangtze River Delta. Through coupling coordination degree measurement, convergence test, spatial correlation analysis and regression analysis of culture and tourism in the major cities in the Yangtze River Delta from 2008 to 2018, it is found that the comprehensive development level of culture and tourism in this region is high, its coupling coordination degree is still low, and there is a growth pole effect around the provincial core cities. The coupling coordination degree of culture and tourism fluctuates in time and forms several types of “small circles”, which are significantly correlated in space. The trend of regional integration is constantly strengthening, but there is no “catch-up” effect among cities. The development of tourism industry has a stronger impact on the integration of culture and tourism than cultural industry. Therefore, the in-depth integrated development of culture and tourism in the Yangtze River Delta should focus on building relevant promotion mechanism, complementing regional characteristics, exerting the effect of growth pole and enhancing the level of internationalization.