Abstract: To attract and retain science and technology talents is particularly important to the economy development for an area. There are many factors affecting the ability of attracting and retaining science and technology talents. It can be found out which are more closely influential factors by the Grey Correlative Analysis Method. The results show that more attention would be focused on the humanistic and natural environment in the selection of some area to settle down, which is different from traditional views that the economic development plays a crucial role. In addition, the real estate price and the investment of educational and scientific research funds are the factors that deserve attention. Meanwhile, we explored the interaction between the ability of attracting and retaining science and technology talents and real estate price taking Beijing, Tianjin and Xi'an as samples. According to the results, we put forward some measures to effectively improve the ability of attracting and retaining science and technology talents for different regions.